Lat Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comLat Polyclonal Antibody for Mouse(Mus musculus)

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Lat (Gene name),

Linker for activation of T-cells family member 1 (Protein name ), LAT_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Lat;

Protein name:

Linker for activation of T-cells family member 1;

Alternative:

p36-38;36 kDa phospho-tyrosine adapter protein(pp36);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB and SKAP2. Interacts with FCGR1A (By similarity). Interacts with CLNK.

Function:

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Subcellular Location:

Cell membrane Single-pass type III membrane protein Present in lipid rafts.

Protein Attributes:

Sequence length:

242

Sequence:

50:

100:

150:

200:

242:

EQQPVTRAEL | ASVNSQEVED | EGEEEGVDGE | EAPDYENLQE | LN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.10280

Pfam:

PF15234

String:

O54957

KEGG:

mmu:16797

Uniprot:

O54957

FOR

ELISA Kit for Mouse Linker for activation of T-cells family member 1

Cat.:

E0270h

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96T

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ELISA Kit for Mouse Linker for activation of T-cells family member 1

Cat.:

E0270m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Linker for activation of T-cells family member 1

Cat.:

E0270r

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96T

CLIA Kit for Mouse Linker for activation of T-cells family member 1

Cat.:

U0270m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Linker for activation of T-cells family member 1

Cat.:

U0270h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Linker for activation of T-cells family member 1

Cat.:

U0270r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Linker for activation of T-cells family member 1

Cat.:

P0270Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Linker for activation of T-cells family member 1

Cat.:

P0270Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Linker for activation of T-cells family member 1

Cat.:

P0270Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Linker for activation of T-cells family member 1

Protein for Mouse Linker for activation of T-cells family member 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation."
Zhang W. , Sloan-Lancaster J. , Kitchen J. , Trible R.P. , Samelson L.E.
Cell92:83-92(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Thymus.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Salivary gland.
3.

"LAT is essential for Fc(epsilon)RI-mediated mast cell activation."
Saitoh S. , Arudchandran R. , Manetz T.S. , Zhang W. , Sommers C.L. , Love P.E. , Rivera J. , Samelson L.E.
Immunity12:525-535(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MAST CELLS;TISSUE SPECIFICITY
4.

"MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT."
Goitsuka R. , Tatsuno A. , Ishiai M. , Kurosaki T. , Kitamura D.
J. Biol. Chem.276:36043-36050(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLNK
5.

"Glucocorticoids alter the lipid and protein composition of membrane rafts of a murine T cell hybridoma."
Van Laethem F. , Liang X. , Andris F. , Urbain J. , Vandenbranden M. , Ruysschaert J.-M. , Resh M.D. , Stulnig T.M. , Leo O.
J. Immunol.170:2932-2939(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION
6.

"LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways."
Sommers C.L. , Samelson L.E. , Love P.E.
Bioessays26:61-67(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN T-CELLS
7.

"Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells."
Hundt M. , Harada Y. , De Giorgio L. , Tanimura N. , Zhang W. , Altman A.
J. Immunol.183:1685-1694(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-27 AND CYS-30
8.

"Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling."
Wang D. , Zheng M. , Lei L. , Ji J. , Yao Y. , Qiu Y. , Ma L. , Lou J. , Ouyang C. , Zhang X. , He Y. , Chi J. , Wang L. , Kuang Y. , Wang J. , Cao X. , Lu L.
Nat. Immunol.13:560-568(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; PLCG1 AND THEMIS
tissue: Thymocyte.

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